Significant advances have been made in recent years in the assessment and interpretation of the non-coding DNA that comprises 98% of our genome. Researchers both within and outside of the ENCODE project are studying gene regulation and expression, non-coding RNA, and other non-coding genome genome functions using multiple data sets and wide-ranging methods including in vitro, high-throughput, statistical, machine learning, and other computational analyses. This year’s meeting will explore these studies and the effects of genetic variation on human disease and other phenotypes. The HGVS invites abstract for both oral and poster presentation. Please follow the instructions on the Abstract Webpage. ABSTRACT CLOSING DATE 15TH JULY 2016.